- Drew is the youngest member of the Drew family of American actors and granddaughter of John Drew.
- Drew first appeared in an advertisement when she was eleven months old.
- Drew made her film debut in Altered States in 1980.
- Drew starred in her breakout role in E.T. The Extra-Terrestrial.
- Drew became one of Hollywood's most recognized child actresses. Following a turbulent childhood which was marked by drug and alcohol abuse and two stints in rehab, Drew wrote the 1990 autobiography, Little Girl Lost.
- Drew successfully made the transition from child star to adult actress with a number of films including the unsuccessful Poison Ivy, Bad Girls, Boys on the Side, and Everyone Says I Love You.
- Subsequently, she established herself in romantic comedies such as The Wedding Singer and Lucky You.
- In 1995, she and partner Nancy Juvonen formed the production company Flower Films, with its first production the 1999 Drew film Never Been Kissed.
- Flower Films has gone on to produce the Drew vehicle films Charlie's Angels, 50 First Dates, and Music and Lyrics, as well as the cult film Donnie Darko.
- Drew's more recent projects include He's Just Not That into You, Beverly Hills Chihuahua, and Everybody's Fine.
- A recipient of a star on the Hollywood Walk of Fame, Drew appeared on the cover of the 2007 People magazine's 100 Most Beautiful issue.
- Drew was named Ambassador Against Hunger for the United Nations World Food Programme (WFP).
- Since then, Drew has donated over $1 million to the program.
- In 2007, she became both CoverGirl's newest model and spokeswoman for the cosmetic and the face for Gucci's newest jewelry line.
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