- Owen got his big break with the 2000 comedy action hit Shanghai Noon, starring opposite Hong Kong action star Jackie Chan. The film grossed nearly US$100 million worldwide.
- wen's fame continued to rise after starring alongside Ben Stiller and Will Ferrell in the 2001 film Zoolander.
- Gene Hackman took notice of Wilson's performance in Shanghai Noon and recommended Wilson to co-star in the 2001 action film Behind Enemy Lines.
- In 2001, Owen and Anderson collaborated on their third film, The Royal Tenenbaums, which was a financial and critical success.
- Owen
partnered Vince Vaughn in the 2005 Wedding Crashers which grossed over $200 million in the US alone.
- In 2006, Wilson provided the voice of Lightning McQueen in the Disney/Pixar film Cars, starred in You, Me and Dupree with Kate Hudson.
- Owen has appeared in nine movies with Ben Stiller (a long-time friend).
- Owen's many collaborations on high-grossing comedy movies have led the media to consider him part of the Frat Pack, along with other comedy actors such as Vince Vaughn, Luke Wilson, Jack Black, Ben Stiller and Will Ferrell.
- In 2007, Owen was taken to St. John's Health after attempting to overdose on drugs and having a slashed wrist. Once stabilized at St. John's, Owen was transferred to Cedars-Sinai Medical Center in Los Angeles, where his condition was initially described as serious, then later described as stable. His lawyer later confirmed that he had been undergoing treatment for depression at the time of his suicide attempt. On August 27, Owen issued a statement: "I respectfully ask that the media allow me to receive care and heal in private during this difficult time."
- Owen made his first public appearance since this incident at the Los Angeles premiere of The Darjeeling Limited.
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