- In 1998 Reese appeared in three major movies: Overnight Delivery, Pleasantville, and Twilight.
- The following year, Reese appeared in the critically acclaimed Election, which earned her a Golden Globe nomination.
- 2001 marked her career's turning point with the breakout role as "Elle Woods" in the box office hit Legally Blonde, and in 2002 Reese starred in Sweet Home Alabama, which became her biggest commercial film success to date.
- 2003 saw Reese return as lead actress and executive producer of Legally Blonde 2.
- In 2005, Reese received worldwide attention and praise for her portrayal of June Carter Cash in Walk the Line, which earned her an Academy Award, Golden Globe, BAFTA, and Screen Actors Guild Award for Best Actress in a Leading Role.
- Reese married actor and Cruel Intentions co-star Ryan Phillippe in 1999; they have two children, Ava and Deacon. However the couple separated at the end of 2006 and divorced in October 2007.
- Reese owns a production company, Type A Films.
- Reese is actively involved in children's and women's advocacy organizations.
- Reese serves on the board of the Children's Defense Fund (CDF).
- At age eleven she took first place in the Ten-State Talent Fair.
- Reese received good grades in school; she loved reading and considered herself "a big dork who read loads of books." On mentioning her love for books, she said, "I get crazy in a bookstore.
- Reese is proud of the "definitive Southern upbringing" she received, which, as she said, gave her "a sense of family and tradition" and taught her about "being conscientious about people's feelings, being polite, and being responsible.
- Reese once said I grew up in an environment where women accomplished a lot.
- Reese's was once called "the new Meg Ryan".
- In 2006, Reese was among a group of actresses who went to New Orleans, Louisiana in a CDF project to bring to light the needs of Hurricane Katrina victims.
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